Hematology
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©2007 by the American Society of Hematology

Print ISSN: 1520-4391; Online ISSN 1520-4383.

Hematology, the American Society of Hematology Education Program Book, is published annually by the American Society of Hematology (ASH) in one volume per year. 

All business correspondence and purchase and reprint requests should be addressed to the American Society of Hematology, 1900 M Street NW, Suite 200, Washington, DC 20036. Telephone: 202-776-0544. Fax: 202-776-0545. E-mail: ASH{at}hematology.org.

Hematology 2007 is available on the Internet at http://www.asheducationbook.org.

©2007 by The American Society of Hematology. All rights reserved. Copyright is not claimed in any works of the United States Government. Except as expressly permitted in this statement, no part of this publication may be used (as hereinafter defined) in any form or by any means now or hereafter known, electronic or mechanical, without permission in writing from the Publisher, The American Society of Hematology. For purposes of this notice, the term "use" includes but is not limited to reproduction, photocopying, storage in a retrieval system, translation, and transmittal. The Publisher hereby consents to the use of this publication or any part hereof for any non-commercial educational purpose within the health field such as classroom instruction, and clinical and residency training. This publication or any part thereof may be used for educational purposes at conferences, continuing education courses, and other educational activity, provided no fee or other compensation is charged therefore. All materials so used must acknowledge the Publisher’s copyright therein as "©2007 by The American Society of Hematology." When requesting the Publisher’s permission to use this publication or any part thereof, please contact the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923, USA; phone: 978-750-8400; fax: 978-750-4470; or The American Society of Hematology Publications Office at 1900 M Street, NW, Suite 200, Washington, DC 20036, USA; phone: 202-776-0544; fax: 202-776-0545.

Article Citations
Cite articles in this volume by listing Author(s), Title, Hematology (Am Soc Hematol Educ Program). 2007; beginning page number-ending page number.

Hematology Rights and Permissions
For instructions on requesting permission to reprint or to order copies of Hematology manuscripts, figures, or tables, please follow the Blood Rights and Permissions guidelines. Questions regarding permissions for Hematology should be directed to bloodpermissions{at}hematology.org.

The publisher disclaims responsibility for opinions expressed by the authors.

Committee on Educational Affairs
Michael E. Williams, MD (2004-2007) [Chair]
Joseph Connors, MD (2006-2007) [Vice Chairperson]
Swati Basu, MBBS (2004-2007)
Kristie A. Blum, MD (2005-2008)
Bertil Glader, MD, PhD (2004-2007)
Lisa Hicks, MD (2007-2010)
Marc Kahn, MD (2007-2010)
Stephanie Lee, MD, MPH (2006-2009)
Sagar Lonial, MD (2007-2010)
Eduardo M. Sotomayor, MD (2005-2008)
F. Marc Stewart, MD (2004-2007)
James W. Vardiman, MD (2007-2009)

Ex Officio:
Andrew I. Schafer, MD (President)
Kenneth Kaushansky, MD (President-Elect)
Nancy Berliner, MD (Vice President)
Armand Keating, MD (Secretary)

Liaisons:
Alan Gewirtz, MD (Education Program Book Editor)
Jane N. Winter, MD (2007 Education Program Co-Chair)
Kenneth S. Zuckerman, MD (2007 Education Program Co-Chair)
Lawrence A. Solberg, Jr., MD, PhD (Chair, Committee on Practice)
John Lazarchick, MD (Co-Editor-in-Chief, Image Bank)
Peter Maslak, MD (Co-Editor-in-Chief, Image Bank)
Shirley Parker Levine, MD (Chair, Teaching Cases Task Force)

Cover: Dr. Katherine A. High. Figure 5. Translational bypass therapy using a small-module drug. (A) In normal translation, the ribosome translates mRNA to produce the polypeptide chain. (B) A nonsense mutation introduces a premature stop codon, resulting in synthesis of a truncated (non-functional) protein. (C) A small-molecule drug permits readthrough of the premature stop codom, restoring normal translation.

The American Society of Hematology is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The American Society of Hematology designates this educational activity for a maximum of 38.25 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity. Physicians not licensed in the United States who participate in this CME activity are also eligible for AMA PRA Category 1 Credits™.

The printing of Hematology 2007 was made possible by an educational grant provided by Amgen.

EDITORS

Alan M. Gerwitz, MD
Executive Editor, Hematology 2007
University of Pennsylvania School of Medicine
Division of Hematology/Oncology
Philadelphia, PA

Janet N. Winter, MD
Co-chair, Education Program
Co-editor, Hematology 2007
Northwestern University
Feinberg School of Medicine
Division of Hematology/Oncology
Chicago, IL

Ken Zuckerman, MD
Co-chair, Education Program
Co-editor, Hematology 2007
Harold H. Davis Professor of Cancer Research
Professor of Oncology, Internal Medicine, and Molecular Medicine
Director, Division of Hematology and Medical Oncology
Director, Hematology/Oncology Fellowship Training Program
University of South Florida and H. Lee Moffitt Cancer Center & Research Institute
Tampa, FL

ASSISTANT EDITOR
PRODUCTION EDITOR

Janine L. Bajus
Seattle, WA


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Copyright © 2008 by the American Society of Hematology.