About the Hematology ASH Education Book

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Print ISSN: 1520-4391; Online ISSN 1520-4383.

Hematology 2008, the American Society of Hematology Education Program Book, is published annually by the American Society of Hematology (ASH) in one volume per year.

All business correspondence and purchase and reprint requests should be addressed to the American Society of Hematology, 1900 M St. NW, Suite 200, Washington, DC 20036, USA; phone: 202-776-0544; fax: 202-776-0545; e-mail: ASH{at}hematology.org.

Hematology 2008 is available on the Internet at http://asheducationbook.hematologylibrary.org/.

©2008 by The American Society of Hematology. All rights reserved. Copyright is not claimed in any works of the United States Government. Except as expressly permitted in this statement, no part of this publication may be used (as hereinafter defined) in any form or by any means now or hereafter known, electronic or mechanical, without permission in writing from the Publisher, The American Society of Hematology. For purposes of this notice, the term “use” includes but is not limited to reproduction, photocopying, storage in a retrieval system, translation, and transmittal. The Publisher hereby consents to the use of this publication or any part hereof for any non-commercial educational purpose within the health field such as classroom instruction and clinical and residency training. This publication or any part thereof may be used for educational purposes at conferences, continuing education courses, and other educational activity, provided no fee or other compensation is charged therefore. All materials so used must acknowledge the Publisher’s copyright therein as “©2008 by The American Society of Hematology.” When requesting the Publisher’s permission to use this publication or any part thereof, please contact the Copyright Clearance Center at 222 Rosewood Dr., Danvers, MA 01923, USA; phone: 978-750-8400; fax: 978-750-4470; or The American Society of Hematology Publications Office at 1900 M St. NW, Suite 200, Washington, DC 20036, USA; phone: 202-776-0544; fax: 202-776-0545.

Article Citations
Cite articles in this volume by listing Author(s), Title, Hematology Am Soc Hematol Educ Program. 2008; beginning page number–ending page number.

Hematology Rights and Permissions
For instructions on requesting permission to reprint or to order copies of Hematology manuscripts, figures, or tables, please follow the Blood Rights and Permissions guidelines. Questions regarding permissions for Hematology should be directed to bloodpermissions{at}hematology.org.

The publisher disclaims responsibility for opinions expressed by the authors.

Committee on Educational Affairs
Joseph Connors, MD (2008–2009) [Chairperson]
Kristie A. Blum, MD (2005–2008)
Bertil Glader, MD, PhD (2004–2011)
Lisa Hicks, MD, FRCPC, MSc (2007–2010)
Marc Kahn, MD (2007–2010)
Michael L. Linenberger, MD (2008–2011)
Sagar Lonial, MD (2007–2010)
Charles T. Quinn, MD (2008–2009)
Jacob M. Rowe, MD (2008–2009)
Mikkael A. Sekeres, MD, MS (2008–2011)
Eduardo M. Sotomayor, MD (2005–2008)
James W. Vardiman, MD (2007–2009)

Ex Officio:
Kenneth Kaushansky, MD (President)
Nancy Berliner, MD (President-Elect)
Hal E. Broxmeyer, MD (Vice President)
Armand Keating, MD (Secretary)

Liaisons:
Alan M. Gewirtz, MD (Education Program Book Editor)
Linda J. Burns, MD (2008 Education Program Co-Chair)
Elaine A. Muchmore, MD (2008 Education Program Co-Chair)
Lawrence A. Solberg, Jr., MD, PhD (Chair, Committee on Practice)
John Lazarchick, MD (Co-Editor-in-Chief, Image Bank)
Peter Maslak, MD (Co-Editor-in-Chief, Image Bank)
Shirley Parker Levine, MD (Chair, Teaching Cases Task Force)

Cover: Monochromatic image of myelodysplastic erythroblasts stained for iron. Adapted from Hellström-Lindberg and Cazzola, Figure 1, middle panel (Perls staining of bone marrow smear showing numerous ringed sideroblasts). Courtesy of Rosangela Invernizzi. See the original, full color figure in the appendix on page 491.

The printing of Hematology 2008 was made possible by an independent medical educational grant from Amgen Oncology.

EDITORS

Alan M. Gewirtz, MD
Executive Editor, Hematology 2008
C. Willard Robinson Professor of Hematology/Oncology
Investigator-Abramson Family Cancer Research Institute
Division of Hematology/Oncology
University of Pennsylvania School of Medicine
Philadelphia, PA

Elaine A. Muchmore, MD
Co-chair, Education Program
Co-editor, Hematology 2008
Professor of Medicine
Division of Hematology/Oncology
University of California San Diego School of Medicine
La Jolla, CA

Linda J. Burns, MD
Co-chair, Education Program
Co-editor, Hematology 2008
Professor of Medicine
Division of Hematology, Oncology and Transplantation
University of Minnesota School of Medicine
Minneapolis, MN