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Pathogenesis and management of essential thrombocythemia

Correspondence: Anthony R. Green, FRCP, FRCPath, FMed, Sci, Deptartment of Haematology, Cambridge Institute for Medical Research, Hills Road, Cambridge, CB2 0XY, UK; Phone: +44 (1223) 336835; Fax: +44 (1223) 762670; e-mail: arg1000{at}cam.ac.uk

Abstract

The last four years have seen an explosion in our understanding of the myeloproliferative neoplasms. Important and often unexpected insights into the molecular mechanisms responsible for these disorders have been accompanied by the development of new diagnostic tests and by an improved understanding of the relationship between the different disease entities. This review will focus on recent developments in the pathogenesis and management of essential thrombocythemia with a particular emphasis on its phenotypic overlap with polycythemia vera and primary myelofibrosis.

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