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Does Helicobacter pylori Eradication Therapy Result in a Platelet Count Improvement in Adults with Immune Thrombocytopenic Purpura Regardless of H pylori Infection?

ASH Evidence-based Review 2008

Correspondence: Donald M. Arnold, 1200 Main Street West, Room 3V-48, Hamilton, Ontario, Canada, L8N 3Z5; Phone 905-521-2100 ext 786305; Fax 905-521-4971; e-mail arnold{at}mcmaster.ca

Abstract

A 34-year-old male with a long history of immune thrombocytopenic purpura (ITP) presents to your office. His platelet count is 30 x 10⁹/L and he is clinically stable with no bleeding symptoms. He has read that Helicobacter pylori eradication therapy may be effective for ITP and he asks you about this. You do not have access to reliable tests for H pylori infection (e.g., urea breath test), yet you wonder about the benefit of empiric eradication therapy for your patient.

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