HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dunbar, C. E. Search for Related Content PubMed PubMed Citation Articles by Dunbar, C. E. Social Bookmarking                   What's this?

The Yin and Yang of Stem Cell Gene Therapy: Insights into Hematopoiesis, Leukemogenesis, and Gene Therapy Safety

Correspondence: Cynthia Dunbar, MD, Hematology Branch, NIH, Building 10, Room 7C103, 9000 Rockville Pike, Bethesda, MD 20892; phone (301) 496-1434; fax (301) 496-8396; dunbarc{at}nhlbi.nih.gov

Abstract

Over the past decade, success in the treatment of serious genetic disorders via gene therapy was finally achieved. However, this progress was tempered by the occurrence of serious adverse events related to vector integration into the genome and activation of adjacent proto-oncogenes. Investigators are now focused on retaining the clinical potential of integrating vectors while decreasing the risk of insertional mutagenesis.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?