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Hematology 2006
© 2006 The American Society of Hematology

Platelets: Testing, Dosing and the Storage Lesion—Recent Advances

Richard M. Kaufman

Correspondence: Richard Kaufman, MD, Brigham and Women’s Hospital, 75 Francis St., Blood Bank; Amory 2-260, Boston MA 02115; Phone 617-732-4749; Fax 617-277-9013; Email rmkaufman{at}partners.org

Abstract

The demand for platelet transfusions continues to grow. Several complementary approaches that may help meet this demand in the future are reviewed. First, platelet bacterial testing is beginning to allow the extension of platelet storage beyond 5 days. Studies are also underway aimed at better preserving viability and function during ex vivo platelet storage: additive solutions and other approaches are being developed to try to negate the "platelet storage lesion." Finally, new approaches to dosing platelets may help extend the limited supply.


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Copyright © 2006 by the American Society of Hematology.