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Hematology 2006
© 2006 The American Society of Hematology

Bisphosphonate Complications Including Osteonecrosis of the Jaw

Bhoomi Mehrotra and Salvatore Ruggiero

Correspondence: Bhoomi Mehtrotra, MD, Long Island Jewish Medical Center, Long Island Campus of the Albert Einstein College of Medicine, 270-05 76th Avenue, New Hyde Park NY 11040; Phone 718-470-7131; Fax 718-470-0169; Email mehrotra{at}lij.edu

Abstract

Bisphosphonate therapy has been incorporated in the standard management of patients with multiple myeloma–related bony disease. Although their efficacy in reducing skeletal related events is important in the supportive management of the myeloma patient, post-marketing experience with this class of agents, particularly the more potent intravenous agents pamidronate and zoledronic acid, have raised cautionary notes regarding the potential side effects of these agents. The focus of this session is to review the risk factors, incidence, prevention strategies and management of bisphosphonate-related osteonecrosis of the jaw. In addition, pathophysiology, incidence and monitoring for renal dysfunction during chronic therapy with these agents are reviewed.


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Copyright © 2006 by the American Society of Hematology.