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Hematology 2006
© 2006 The American Society of Hematology

An Update on Therapy of Primary Central Nervous System Lymphoma

Lisa M. DeAngelis and Fabio M. Iwamoto

Correspondence: Lisa M. DeAngelis, MD. Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021; Phone 212-639-7997; Fax 212-717-3296; Email deangell{at}mskcc.org

Abstract

The most important advance in primary central nervous system (CNS) lymphoma treatment has been the convincing data that high-dose methotrexate-based chemotherapy regimens improve survival compared to historical controls treated with radiotherapy alone. However, the optimal treatment approach is still unclear and therapy can be associated with long-term neurotoxicity. Current research focuses on maximizing survival while minimizing neurologic sequelae.


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Copyright © 2006 by the American Society of Hematology.