Hematology
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Hematology 2006
© 2006 The American Society of Hematology

Controversies in Treatment of AML: Case-based Discussion

Wendy Stock

Correspondence: Wendy Stock, MD, University of Chicago, Section Hem./Onc., 5841 S Maryland, M/C 2115, Chicago IL 60637-1463; Phone 773-834-78982; Fax 773-702-0963; Email wstock{at}medicine.bsd.uchicago.edu

Abstract

Treatment of acute myeloid leukemia (AML) in older adults remains a tremendous challenge. Standard approaches to treatment have resulted in progression-free survival in only a small minority of patients with AML over the age of 60. Elucidation of the molecular genetic events that contribute to the pathogenesis of AML in older patients are providing insights into mechanisms of resistance. This knowledge is also providing new opportunities to begin to refine and direct novel therapies for these heterogeneous diseases. In this case-based review, prognostic factors for treatment outcome in older adults will be covered along with discussion of a risk-based approach to potential therapeutic options, ranging from palliative care to novel therapies and reduced-intensity allogenenic transplant.


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Copyright © 2006 by the American Society of Hematology.