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Hematology 2005
© 2005 The American Society of Hematology

Inherited Platelet Disorders

Robert I. Handin

Correspondence: Robert I. Handin, MD, Brigham & Women’s Hospital, Hematology Division, 75 Francis Street, Boston MA 02115-6110; Phone (617) 732-5840, Fax (617) 732-5706, rhandin{at}partners.org

Abstract

The inherited platelet disorders are a heterogeneous collection of rare diseases that are infrequently encountered in clinical practice. They are, however, fascinating abnormalities, which have taught us a great deal about normal platelet biochemistry and physiology. In this section of the presentation we will review disorders of the platelet membrane, platelet granule packaging disorders, the hereditary macrothrombocytopenias, platelet signaling disorders and disorders of platelet coagulant function. The molecular basis of the disorders, the cardinal features of their clinical presentation and best methods to make their diagnosis and the latest information regarding therapy will be presented.


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Copyright © 2005 by the American Society of Hematology.