Hematology
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Hematology 2005
© 2005 The American Society of Hematology

Solitary Bone and Extramedullary Plasmacytoma

Donna M. Weber

Correspondence: Donna Weber, MD, University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 001, Houston TX 77030; Phone: (713) 792-2850, Fax: (713) 796-9734, dmweber{at}mdanderson.org

Abstract

Less than 5% of patients with a plasma cell dyscrasia present with a single bone (SBP) or extramedullary plasmacytoma (EMP) without evidence of systemic disease (normocalcemia, absence of anemia, preservation of uninvolved immunoglobulins, or renal disease attributable to myeloma). Diagnosis requires biopsy confirmation of a monoclonal plasma cell infiltrate from a single site. The treatment of choice for both entities is radiotherapy given with curative intent (> 4000 cGy) resulting in long term disease-free survival in approximately 30% of patients with SBP and 65% of patients with EMP.


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Copyright © 2005 by the American Society of Hematology.