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Hematology 2005
© 2005 The American Society of Hematology

MGUS and Smoldering Multiple Myeloma: Update on Pathogenesis, Natural History, and Management

S. Vincent Rajkumar

Correspondence: S. Vincent Rajkumar, MD, Mayo Clinic College of Medicine, Division of Hematology, 200 First Avenue St., SW, Rochester MN 55905; Phone: (507) 284-2176, Fax: (507) 266-4972, rajks{at}mayo.edu

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic, pre-malignant disorders characterized by monoclonal plasma cell proliferation in the bone marrow and absence of end-organ damage. Recent advances in the pathogenesis, natural history, and prognosis of MGUS and SMM are reviewed. A new risk stratification system to determine the prognosis of MGUS using the size and type of M protein, and the serum free light chain assay is discussed.


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Copyright © 2005 by the American Society of Hematology.