Hematology
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Hematology 2005
© 2005 The American Society of Hematology

Role of Allogeneic Stem Cell Transplantation in Current Treatment of Acute Myeloid Leukemia

Jan J. Cornelissen and Bob Löwenberg

Correspondence: Jan J. Cornelissen, MD, PhD, Erasmus University Medical Center/Daniel Den Hoed Cancer Center, Groene Hilledijk 301, Rotterdam 3075 EA, The Netherlands; Phone +31 (10) 4391367, Fax +31 (10) 4391004, j.cornelissen{at}erasmusmc.nl

Abstract

Allogeneic hematopoietic stem cell transplantation (alloSCT) has been established as an effective consolidation therapy in acute myeloid leukemia (AML) in first or subsequent remission. Although it effectively prevents relapse, treatment-related mortality (TRM) associated with alloSCT may compromise that beneficial effect. As a result, alloSCT may be restricted to patients with a relatively high risk of relapse. Here, we review studies that identify categories of AML patients who may specifically benefit from alloSCT. In addition, we discuss recent developments with respect to alternative donors, stem cell sources, and supportive care. Finally, we highlight recent results obtained with reduced-intensity alloSCT, which already significantly influence our therapeutic strategy in elderly patients with AML.


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Copyright © 2005 by the American Society of Hematology.