Hematology
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Hematology 2005
© 2005 The American Society of Hematology

The Molecular Pathology of Acute Myeloid Leukemia

Jonathan D. Licht and David W. Sternberg

Correspondence: Jonathan D. Licht, MD, Mt. Sinai School of Medicine, Division of Hematology/Oncology, One Gustave L. Levy Pl., Box 1079, New York NY 10029-6504; Phone (212) 241-8220, Fax (212) 849-2523, jonathan.licht{at}mssm.edu

Abstract

The pathogenesis of acute myelogenous leukemia (AML) involves an array of molecular alterations that disrupt almost every facet of cell transformation. These processes include the regulation of cell proliferation, differentiation, self-renewal, survival, cell cycle checkpoint control, DNA repair and chromatin stability, and cell dissemination. Normal regulatory networks are disrupted or usurped by these leukemogenic insults, and the understanding of these alterations is guiding the design of new therapeutic strategies. This overview describes some of the critical molecular alterations and implicates the rogue leukemogenic proteins in the onset and progression of AML.


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Copyright © 2005 by the American Society of Hematology.