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Hematology 2000
© 2000 The American Society of Hematology

New Views of Sickle Cell Disease Pathophysiology and Treatment

Wendell F. Rosse, (Chair), Mohandas Narla, Lawrence D. Petz and Martin H. Steinberg

Abstract

This review addresses several areas of concern in the care of patients with sickle cell disease. In Sections I and II, the fundamental pathogenetic mechanisms of sickle cell disease and their clinical consequences are discussed. Dr. Narla presents the evidence for abnormal cell adhesiveness by SS cells and Dr. Rosse examines the role of the increased whole blood viscosity. In Section III, Dr. Petz reviews common and uncommon alloimmune consequences of transfusion in sickle cell disease and discusses the diagnosis and management of sickle cell patients with hyperhemolysis after transfusion. In Section IV, Dr. Steinberg gives an update on the use of hydroxyurea in the treatment of sickle cell disease, including the SC and S-ß thalassemia variants.


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Copyright © 2000 by the American Society of Hematology.